Associations between genetic polymorphisms and bipolar disorder

11/02/2013 11:48


Bipolar disorder (BD) is a common disorder that a!ects approximately 1% of the population. It is associated with both chronic and acute severe features, such
as low remission rates and a high prevalence of clinical and psychiatric comorbidities. "e aim of the present article is to synthesize data from various articles
that investigated genetic polymorphisms associated with BD. "e 129 articles selected identi#ed 79 (85.87%) genes associated with BD. "is analysis identi#ed
the #ve genes that are the most cited in the literature: CANAC1C, DAOA, TPH2, ANK3 and DISC1. Of the 92 genes identi#ed in these articles, 33 (35.87%)
showed no association with BD. "is analysis showed that, despite recent advances with respect to the role of genetic polymorphism in predisposition to BD,
further research is still required to elucidate its in$uence on this disorder.
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